Superoxide-dependent and -independent nitrite formation from hydroxylamine: inhibition by plant extracts.
Identifieur interne : 004910 ( Main/Exploration ); précédent : 004909; suivant : 004911Superoxide-dependent and -independent nitrite formation from hydroxylamine: inhibition by plant extracts.
Auteurs : U. Rohnert [Allemagne] ; W. Schneider ; E F ElstnerSource :
- Zeitschrift fur Naturforschung. C, Journal of biosciences [ 0939-5075 ]
Descripteurs français
- KwdFr :
- Activation des neutrophiles (MeSH), Anti-inflammatoires non stéroïdiens (composition chimique), Antioxydants (composition chimique), Arbres (MeSH), Espèces réactives de l'oxygène (MeSH), Extraits de plantes (composition chimique), Hydroxylamine (composition chimique), Myoglobine (composition chimique), Nitrites (MeSH), Radical hydroxyle (MeSH), Xanthine oxidase (métabolisme).
- MESH :
- composition chimique : Anti-inflammatoires non stéroïdiens, Antioxydants, Extraits de plantes, Hydroxylamine, Myoglobine.
- métabolisme : Xanthine oxidase.
- Activation des neutrophiles, Arbres, Espèces réactives de l'oxygène, Nitrites, Radical hydroxyle.
English descriptors
- KwdEn :
- Anti-Inflammatory Agents, Non-Steroidal (chemistry), Antioxidants (chemistry), Hydroxyl Radical (MeSH), Hydroxylamine (chemistry), Myoglobin (chemistry), Neutrophil Activation (MeSH), Nitrites (MeSH), Plant Extracts (chemistry), Reactive Oxygen Species (MeSH), Trees (MeSH), Xanthine Oxidase (metabolism).
- MESH :
- chemical , chemistry : Anti-Inflammatory Agents, Non-Steroidal, Antioxidants, Hydroxylamine, Myoglobin, Plant Extracts.
- chemical , metabolism : Xanthine Oxidase.
- chemical : Hydroxyl Radical, Nitrites, Reactive Oxygen Species.
- Neutrophil Activation, Trees.
Abstract
Reactive oxygen species such as OH, peroxynitrite and the non-radical, hypochlorous acid, play outstanding roles in many disease. The formation of OH (Fenton)-type radicals is catalyzed by enzymes such as xanthine oxidase (XOD) via one-electron reduction of molecular oxygen producing superoxide radical anions (O2). Subsequent transfer of one electron to hydrogen peroxide by Fe2+ or Cu+ -ions yields OH-radicals measurable as ethene release from 1-keto-4-methylthiobutyrate (KMB). Xanthine oxidase or activated neutrophils are prominent sources of this strong oxidant produced at inflammatory sites. Many natural compounds such as salicylates or flavonoids interfere either with the production of these activated oxygen species or function as radical scavengers and thus as antioxidants. Extracts from willow-bark (Salix spec.) and also other species such as ash-tree (Fraxinus spec.) or poplar (Populus spec.) have been used as antiinflammatory drugs since a long time. In this communication we wish to report on model reactions to demonstrate a) the radical scavenging activities of such plant extracts inhibiting ethene release from KMB induced by Fenton-type oxidants and b) the inhibition of the formation of nitrogen monoxide (NO) from hydroxylamine including XOD either in the presence or absence of myoglobin (MYO) measurable as nitrite formation: In the absence of MYO, superoxide dismutase is an excellent inhibitor of nitrite formation but is inactive in its presence. Extracts from the willow-bark or the drug Phytodolar however, are inhibitory both in the presence and absence of MYO. As active principle, the flavonoid rutin included in these extracts is likely to function as one inhibitor of the XOD-mediated reaction.
DOI: 10.1515/znc-1998-3-414
PubMed: 9687163
Affiliations:
Links toward previous steps (curation, corpus...)
Le document en format XML
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Rohnert</name><affiliation wicri:level="4"><nlm:affiliation>Lehrstuhl für Phytopathologie, Technische Universität München, Freising-Weihenstephan, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Lehrstuhl für Phytopathologie, Technische Universität München, Freising-Weihenstephan</wicri:regionArea><wicri:noRegion>Freising-Weihenstephan</wicri:noRegion><orgName type="university">Université technique de Munich</orgName><placeName><settlement type="city">Munich</settlement><region type="land" nuts="1">Bavière</region><region type="district" nuts="2">District de Haute-Bavière</region></placeName></affiliation></author><author><name sortKey="Schneider, W" sort="Schneider, W" uniqKey="Schneider W" first="W" last="Schneider">W. Schneider</name></author><author><name sortKey="Elstner, E F" sort="Elstner, E F" uniqKey="Elstner E" first="E F" last="Elstner">E F Elstner</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="1998">1998 Mar-Apr</date><idno type="RBID">pubmed:9687163</idno><idno type="pmid">9687163</idno><idno type="doi">10.1515/znc-1998-3-414</idno><idno type="wicri:Area/Main/Corpus">004953</idno><idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Corpus" wicri:corpus="PubMed">004953</idno><idno type="wicri:Area/Main/Curation">004953</idno><idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Curation">004953</idno><idno type="wicri:Area/Main/Exploration">004953</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Superoxide-dependent and -independent nitrite formation from hydroxylamine: inhibition by plant extracts.</title><author><name sortKey="Rohnert, U" sort="Rohnert, U" uniqKey="Rohnert U" first="U" last="Rohnert">U. Rohnert</name><affiliation wicri:level="4"><nlm:affiliation>Lehrstuhl für Phytopathologie, Technische Universität München, Freising-Weihenstephan, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Lehrstuhl für Phytopathologie, Technische Universität München, Freising-Weihenstephan</wicri:regionArea><wicri:noRegion>Freising-Weihenstephan</wicri:noRegion><orgName type="university">Université technique de Munich</orgName><placeName><settlement type="city">Munich</settlement><region type="land" nuts="1">Bavière</region><region type="district" nuts="2">District de Haute-Bavière</region></placeName></affiliation></author><author><name sortKey="Schneider, W" sort="Schneider, W" uniqKey="Schneider W" first="W" last="Schneider">W. Schneider</name></author><author><name sortKey="Elstner, E F" sort="Elstner, E F" uniqKey="Elstner E" first="E F" last="Elstner">E F Elstner</name></author></analytic><series><title level="j">Zeitschrift fur Naturforschung. C, Journal of biosciences</title><idno type="ISSN">0939-5075</idno></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Anti-Inflammatory Agents, Non-Steroidal (chemistry)</term><term>Antioxidants (chemistry)</term><term>Hydroxyl Radical (MeSH)</term><term>Hydroxylamine (chemistry)</term><term>Myoglobin (chemistry)</term><term>Neutrophil Activation (MeSH)</term><term>Nitrites (MeSH)</term><term>Plant Extracts (chemistry)</term><term>Reactive Oxygen Species (MeSH)</term><term>Trees (MeSH)</term><term>Xanthine Oxidase (metabolism)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Activation des neutrophiles (MeSH)</term><term>Anti-inflammatoires non stéroïdiens (composition chimique)</term><term>Antioxydants (composition chimique)</term><term>Arbres (MeSH)</term><term>Espèces réactives de l'oxygène (MeSH)</term><term>Extraits de plantes (composition chimique)</term><term>Hydroxylamine (composition chimique)</term><term>Myoglobine (composition chimique)</term><term>Nitrites (MeSH)</term><term>Radical hydroxyle (MeSH)</term><term>Xanthine oxidase (métabolisme)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="chemistry" xml:lang="en"><term>Anti-Inflammatory Agents, Non-Steroidal</term><term>Antioxidants</term><term>Hydroxylamine</term><term>Myoglobin</term><term>Plant Extracts</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Xanthine Oxidase</term></keywords><keywords scheme="MESH" type="chemical" xml:lang="en"><term>Hydroxyl Radical</term><term>Nitrites</term><term>Reactive Oxygen Species</term></keywords><keywords scheme="MESH" qualifier="composition chimique" xml:lang="fr"><term>Anti-inflammatoires non stéroïdiens</term><term>Antioxydants</term><term>Extraits de plantes</term><term>Hydroxylamine</term><term>Myoglobine</term></keywords><keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Xanthine oxidase</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Neutrophil Activation</term><term>Trees</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Activation des neutrophiles</term><term>Arbres</term><term>Espèces réactives de l'oxygène</term><term>Nitrites</term><term>Radical hydroxyle</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Reactive oxygen species such as OH, peroxynitrite and the non-radical, hypochlorous acid, play outstanding roles in many disease. The formation of OH (Fenton)-type radicals is catalyzed by enzymes such as xanthine oxidase (XOD) via one-electron reduction of molecular oxygen producing superoxide radical anions (O2). Subsequent transfer of one electron to hydrogen peroxide by Fe2+ or Cu+ -ions yields OH-radicals measurable as ethene release from 1-keto-4-methylthiobutyrate (KMB). Xanthine oxidase or activated neutrophils are prominent sources of this strong oxidant produced at inflammatory sites. Many natural compounds such as salicylates or flavonoids interfere either with the production of these activated oxygen species or function as radical scavengers and thus as antioxidants. Extracts from willow-bark (Salix spec.) and also other species such as ash-tree (Fraxinus spec.) or poplar (Populus spec.) have been used as antiinflammatory drugs since a long time. In this communication we wish to report on model reactions to demonstrate a) the radical scavenging activities of such plant extracts inhibiting ethene release from KMB induced by Fenton-type oxidants and b) the inhibition of the formation of nitrogen monoxide (NO) from hydroxylamine including XOD either in the presence or absence of myoglobin (MYO) measurable as nitrite formation: In the absence of MYO, superoxide dismutase is an excellent inhibitor of nitrite formation but is inactive in its presence. Extracts from the willow-bark or the drug Phytodolar however, are inhibitory both in the presence and absence of MYO. As active principle, the flavonoid rutin included in these extracts is likely to function as one inhibitor of the XOD-mediated reaction.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">9687163</PMID><DateCompleted><Year>1998</Year><Month>07</Month><Day>28</Day></DateCompleted><DateRevised><Year>2019</Year><Month>10</Month><Day>21</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Print">0939-5075</ISSN><JournalIssue CitedMedium="Print"><Volume>53</Volume><Issue>3-4</Issue><PubDate><MedlineDate>1998 Mar-Apr</MedlineDate></PubDate></JournalIssue><Title>Zeitschrift fur Naturforschung. C, Journal of biosciences</Title><ISOAbbreviation>Z Naturforsch C J Biosci</ISOAbbreviation></Journal><ArticleTitle>Superoxide-dependent and -independent nitrite formation from hydroxylamine: inhibition by plant extracts.</ArticleTitle><Pagination><MedlinePgn>241-9</MedlinePgn></Pagination><Abstract><AbstractText>Reactive oxygen species such as OH, peroxynitrite and the non-radical, hypochlorous acid, play outstanding roles in many disease. The formation of OH (Fenton)-type radicals is catalyzed by enzymes such as xanthine oxidase (XOD) via one-electron reduction of molecular oxygen producing superoxide radical anions (O2). Subsequent transfer of one electron to hydrogen peroxide by Fe2+ or Cu+ -ions yields OH-radicals measurable as ethene release from 1-keto-4-methylthiobutyrate (KMB). Xanthine oxidase or activated neutrophils are prominent sources of this strong oxidant produced at inflammatory sites. Many natural compounds such as salicylates or flavonoids interfere either with the production of these activated oxygen species or function as radical scavengers and thus as antioxidants. Extracts from willow-bark (Salix spec.) and also other species such as ash-tree (Fraxinus spec.) or poplar (Populus spec.) have been used as antiinflammatory drugs since a long time. In this communication we wish to report on model reactions to demonstrate a) the radical scavenging activities of such plant extracts inhibiting ethene release from KMB induced by Fenton-type oxidants and b) the inhibition of the formation of nitrogen monoxide (NO) from hydroxylamine including XOD either in the presence or absence of myoglobin (MYO) measurable as nitrite formation: In the absence of MYO, superoxide dismutase is an excellent inhibitor of nitrite formation but is inactive in its presence. Extracts from the willow-bark or the drug Phytodolar however, are inhibitory both in the presence and absence of MYO. As active principle, the flavonoid rutin included in these extracts is likely to function as one inhibitor of the XOD-mediated reaction.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Rohnert</LastName><ForeName>U</ForeName><Initials>U</Initials><AffiliationInfo><Affiliation>Lehrstuhl für Phytopathologie, Technische Universität München, Freising-Weihenstephan, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Schneider</LastName><ForeName>W</ForeName><Initials>W</Initials></Author><Author ValidYN="Y"><LastName>Elstner</LastName><ForeName>E F</ForeName><Initials>EF</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>Germany</Country><MedlineTA>Z Naturforsch C J Biosci</MedlineTA><NlmUniqueID>8912155</NlmUniqueID><ISSNLinking>0341-0382</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D000894">Anti-Inflammatory Agents, Non-Steroidal</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D000975">Antioxidants</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D009211">Myoglobin</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D009573">Nitrites</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D010936">Plant Extracts</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D017382">Reactive Oxygen Species</NameOfSubstance></Chemical><Chemical><RegistryNumber>141444-11-3</RegistryNumber><NameOfSubstance UI="C092917">Phytodolor N</NameOfSubstance></Chemical><Chemical><RegistryNumber>2FP81O2L9Z</RegistryNumber><NameOfSubstance UI="D019811">Hydroxylamine</NameOfSubstance></Chemical><Chemical><RegistryNumber>3352-57-6</RegistryNumber><NameOfSubstance UI="D017665">Hydroxyl Radical</NameOfSubstance></Chemical><Chemical><RegistryNumber>EC 1.17.3.2</RegistryNumber><NameOfSubstance UI="D014969">Xanthine Oxidase</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000894" MajorTopicYN="N">Anti-Inflammatory Agents, Non-Steroidal</DescriptorName><QualifierName UI="Q000737" MajorTopicYN="N">chemistry</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D000975" MajorTopicYN="N">Antioxidants</DescriptorName><QualifierName UI="Q000737" MajorTopicYN="Y">chemistry</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D017665" MajorTopicYN="N">Hydroxyl Radical</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D019811" MajorTopicYN="N">Hydroxylamine</DescriptorName><QualifierName UI="Q000737" MajorTopicYN="Y">chemistry</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D009211" MajorTopicYN="N">Myoglobin</DescriptorName><QualifierName UI="Q000737" MajorTopicYN="N">chemistry</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D018375" MajorTopicYN="N">Neutrophil Activation</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D009573" MajorTopicYN="Y">Nitrites</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D010936" MajorTopicYN="N">Plant Extracts</DescriptorName><QualifierName UI="Q000737" MajorTopicYN="Y">chemistry</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D017382" MajorTopicYN="N">Reactive Oxygen Species</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D014197" MajorTopicYN="N">Trees</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D014969" MajorTopicYN="N">Xanthine Oxidase</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="pubmed"><Year>1998</Year><Month>8</Month><Day>1</Day></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>1998</Year><Month>8</Month><Day>1</Day><Hour>0</Hour><Minute>1</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>1998</Year><Month>8</Month><Day>1</Day><Hour>0</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">9687163</ArticleId><ArticleId IdType="doi">10.1515/znc-1998-3-414</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>Allemagne</li></country><region><li>Bavière</li><li>District de Haute-Bavière</li></region><settlement><li>Munich</li></settlement><orgName><li>Université technique de Munich</li></orgName></list><tree><noCountry><name sortKey="Elstner, E F" sort="Elstner, E F" uniqKey="Elstner E" first="E F" last="Elstner">E F Elstner</name><name sortKey="Schneider, W" sort="Schneider, W" uniqKey="Schneider W" first="W" last="Schneider">W. Schneider</name></noCountry><country name="Allemagne"><region name="Bavière"><name sortKey="Rohnert, U" sort="Rohnert, U" uniqKey="Rohnert U" first="U" last="Rohnert">U. Rohnert</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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